Pesquisa sobre:
APOPTOSIS INDUCING FACTOR
Descritores Encontrados:
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DeCS
Descritor
Inglês
:
Apoptosis Inducing Factor
Descritor
Espanhol
:
Factor Inductor de la Apoptosis
Descritor
Português
:
Fator de Indução de Apoptose
Categoria:
D08.811.682.608.047
D12.644.360.075.311
D12.776.331.161
D12.776.476.075.311
Definição
Inglês
:
A flavoprotein that functions as a powerful antioxidant in the
MITOCHONDRIA
and promotes
APOPTOSIS
when released from the
mitochondria
. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein
family
. It translocates to the
CELL NUCLEUS
and binds DNA to stimulate CASPASE-independent
CHROMATIN
condensation.
Nota de Indexação
Inglês
:
INHIBITOR OF APOPTOSIS PROTEINS
is also available
Nota Histórica
Inglês
:
2006(1999)
Qualificadores Permitidos
Inglês
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número do Registro:
50601
Identificador Único:
D051033
Ocorrência na BVS
:
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